Article
MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise.
Nature communications - 1 Jan 2013
Siciliano Velia, Garzilli Immacolata, Fracassi Chiara, Criscuolo Stefania, Ventre Simona, di Bernardo Diego
Abstract excerpt
miRNAs are small non-coding RNAs able to modulate target gene expression. It has been postulated that miRNAs confer robustness to biological processes, but clear experimental evidence is still missing. Here, using a synthetic biological approach, we demonstrate that microRNAs provide phenotypic robustness to transcriptional regulatory networks by buffering fluctuations in protein levels. We construct a network...
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