Article

Cytoplasmic import and processing of mRNA amplify transcriptional bursts accounting for the majority of cellular noise

2017-11-21

Abstract excerpt

Transcription is an episodic process characterized by probabilistic bursts; but how these bursts are modulated by cellular physiology remains unclear and has implications for how selection may act on these fluctuations. Using simulations and single-molecule RNA counting, we examined how cellular processes influence cell-to-cell variability (noise). The results show that RNA noise is amplified in the cytoplasm comp...

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Literature Corpus work: 763e7fc7-f972-55a4-b85f-b69c9773ea87
DOI: 10.1101/222901

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