Article

From foodwebs to gene regulatory networks (GRNs) - weak repressions by microRNAs confer system stability

2017-08-15

Abstract excerpt

More than 30% of mRNAs are repressed by microRNAs (miRNAs) but most repressions are too weak to have a phenotypic consequence. The diffuse actions have been a central conundrum in understanding the functions of miRNAs. By applying the May-Wigner theory used in foodweb studies, we show that i) weak repressions cumulatively enhance the stability of gene regulatory network (GRN), and ii) broad and weak repressions co...

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Literature Corpus work: 289e096e-cea2-5a2a-b77d-af624a61e536
DOI: 10.1101/176701

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