Article

Inverted translational control of eukaryotic gene expression by ribosome collisions

2019-02-27

Abstract excerpt

The canonical model of eukaryotic translation posits that efficient translation initiation increases protein expression and mRNA stability. Contrary to this dogma, we show that increasing initiation rate can decrease both protein expression and stability of certain mRNAs in the budding yeast, S. cerevisiae . These mRNAs contain a stretch of poly-basic residues that cause ribosome stalling. Using computational mod...

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Literature Corpus work: df804fa9-f263-5d3c-96cd-2d013b49546f
DOI: 10.1101/562371

Open publication

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