Article

Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms

2018-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Co-measurement of multiple omic profiles from the same single cells opens up the opportunity to decode molecular regulation that underlie intercellular heterogeneity in development and disease. Here, we present co-sequencing of microRNAs and mRNAs in the same single cells using a half-cell genomics approach. This method demonstrates good robustness (~95% success rate) and reproducibility (R 2 =...

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Literature Corpus work: 5dd65002-7799-5f07-8462-f5653d1ebd6a
DOI: 10.1101/431213

Open publication

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