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The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

3 Jun 2019

Abstract excerpt

DNA replication initiation is a two-step process. During the G1-phase of the cell cycle, the ORC complex, CDC6, CDT1, and MCM2-7 assemble at replication origins, forming pre-replicative complexes (pre-RCs). In S-phase, kinase activities allow fork establishment through (CDC45/MCM2-7/GINS) CMG-complex formation. However, only a subset of all potential origins becomes activated, through a poorly understood...

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PMID: 31160578
DOI: 10.1038/s41467-019-10321-x

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