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Article

Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences.

Nucleic acids research - 10 Jun 2024

Chappleboim Michal, Naveh-Tassa Segev, Carmi Miri, Levy Yaakov, Barkai Naama

Abstract excerpt

The Origin Recognition Complex (ORC) seeds replication-fork formation by binding to DNA replication origins, which in budding yeast contain a 17bp DNA motif. High resolution structure of the ORC-DNA complex revealed two base-interacting elements: a disordered basic patch (Orc1-BP4) and an insertion helix (Orc4-IH). To define the ORC elements guiding its DNA binding in vivo, we mapped genomic locations of 38...

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Identifiers

PMID: 38597680
DOI: 10.1093/nar/gkae249
PMCID: PMC11162778

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