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Article

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease.

Alzheimer's research & therapy - 31 Oct 2020

Baek Min Seok, Cho Hanna, Lee Hye Sun, Lee Jae Hoon, Ryu Young Hoon, Lyoo Chul Hyoung

Abstract excerpt

BACKGROUND: To assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ) and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum. METHODS: Among 272 individuals who underwent PET scans (18F-florbetaben for Aβ and 18F-flortaucipir for tau) and ApoE genotyping, 187 individuals completed 2-year follow-up PET scans. After correcting for the partial volume effect, we...

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Identifiers

PMID: 33129364
DOI: 10.1186/s13195-020-00710-6
PMCID: PMC7603688

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