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Article

ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner.

Brain : a journal of neurology - 3 Jun 2026

Steward Anna, Dewenter Anna, Hirsch Fabian, Roemer-Cassiano Sebastian N, Zhu Zeyu, Dehsarvi Amir, Biel Davina, Klonowski Madleen, Frontzkowski Lukas, Palleis Carla, Gnörich Johannes, Dichgans Martin, Höglinger Günter, Brendel Matthias, Franzmeier Nicolai

Abstract excerpt

In Alzheimer's disease, carriage of the apolipoprotein E ε4 (ApoE4) risk allele is linked to faster tau accumulation at lower amyloid-PET levels, thereby accelerating disease progression. However, it remains unclear whether this ApoE4-facilitated transition from amyloidosis to tauopathy is mechanistically promoted by increased secretion of phosphorylated tau (ptau), a key intermediate that drives the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41410687
DOI: 10.1093/brain/awaf463

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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