APOEε4 potentiates amyloid β effects on longitudinal tau pathology.

doi:10.1038/s43587-023-00490-2

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Article

APOEε4 potentiates amyloid β effects on longitudinal tau pathology.

Nature aging - 1 Oct 2023

Ferrari-Souza João Pedro, Bellaver Bruna, Ferreira Pâmela C L, Benedet Andréa L, Povala Guilherme, Lussier Firoza Z, Leffa Douglas T, Therriault Joseph, Tissot Cécile, Soares Carolina, Wang Yi-Ting, Chamoun Mira, Servaes Stijn, Macedo Arthur C, Vermeiren Marie, Bezgin Gleb, Kang Min Su, Stevenson Jenna, Rahmouni Nesrine, Pallen Vanessa, Poltronetti Nina Margherita, Cohen Ann, Lopez Oscar L, Klunk William E, Soucy Jean-Paul, Gauthier Serge, Souza Diogo O, Triana-Baltzer Gallen, Saad Ziad S, Kolb Hartmuth C, Karikari Thomas K, Villemagne Victor L, Tudorascu Dana L, Ashton Nicholas J, Zetterberg Henrik, Blennow Kaj, Zimmer Eduardo R, Rosa-Neto Pedro, Pascoal Tharick A

Abstract excerpt

The mechanisms by which the apolipoprotein E ε4 (APOEε4) allele influences the pathophysiological progression of Alzheimer's disease (AD) are poorly understood. Here we tested the association of APOEε4 carriership and amyloid-β (Aβ) burden with longitudinal tau pathology. We longitudinally assessed 94 individuals across the aging and AD spectrum who underwent clinical assessments, APOE genotyping, magnetic...

Topics

Humans
Alzheimer Disease
Amyloid beta-Peptides
Magnetic Resonance Imaging
Positron-Emission Tomography
tau Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Apolipoprotein E4

Heterozygote

Alleles

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Identifiers

PMID: 37749258
DOI: 10.1038/s43587-023-00490-2
PMCID: PMC10592050

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