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Article

Effects of APOE ε4 and amyloid pathology on longitudinal tau biomarkers, neurodegeneration, and cognitive decline in mild cognitive impairment.

Journal of Alzheimer's disease : JAD - 1 May 2026

Wang Xitian, Zhang Chunhua, Liu Xiaocong, Tai Yaojun, Ma Guozhao, Kong Min, Ba Maowen

Abstract excerpt

BackgroundMild cognitive impairment (MCI) confers an increased risk of Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for late-onset AD and is strongly associated with amyloid-β (Aβ) pathology. However, whether Aβ burden is associated with APOE ε4-related longitudinal changes in tau pathology, neurodegeneration, and cognitive decline in MCI remains incompletely...

Topics

Humans
Cognitive Dysfunction
tau Proteins
Male
Apolipoprotein E4
Female
Aged
Longitudinal Studies
Biomarkers
Amyloid beta-Peptides
Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Brain

Genotype

Magnetic Resonance Imaging

Source

Identifiers

PMID: 41910460
DOI: 10.1177/13872877261435429

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41910460-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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