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Article

Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum.

Molecular neurobiology - 1 Sept 2016

Liu Ying, Tan Lan, Wang Hui-Fu, Liu Yong, Hao Xiao-Ke, Tan Chen-Chen, Jiang Teng, Liu Bing, Zhang Dao-Qiang, Yu Jin-Tai

Abstract excerpt

The apolipoprotein E ε4 (APOE ε4) allele is the most important genetic risk factor for Alzheimer's disease (AD); however, the underlying mechanisms responsible for it remain controversial. We used the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to examine the influence of APOE ε4 dose on clinical and neuroimaging biomarkers across the AD spectrum (from cognitive normal to AD patients with severe...

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Identifiers

PMID: 26298664
DOI: 10.1007/s12035-015-9388-7

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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