Article

APOE ε4 carriership status enhances age-related changes in Alzheimer’s disease plasma biomarkers concentrations

2026-05-12

Abstract excerpt

<title>Abstract</title> <p> Alzheimer’s disease (AD) plasma biomarkers are cost-effective tools to detect early stage amyloid pathology. We investigated how interactions between AD genetic risk (apolipoprotein E ( <italic>APOE</italic> ) ε4, AD polygenic risk score (excluding <italic>APOE;</italic> PRS <sub>AD</sub> )), age, and sex affected AD plasma biomarkers concentrations in a population-based cohort....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2099ee2-df2d-5f68-86de-e3dfef13bc42
DOI: 10.21203/rs.3.rs-8426026/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOE ε4 carriership status enhances age-related changes in Alzheimer’s disease plasma biomarkers concentrationsDOI 10.21203/rs.3.rs-8426026/v1Read

Plasma biomarkers predict amyloid conversion and cognitive decline in cognitively unimpaired adultsSemantic proximity Read

APOEε4 potentiates Aβ effects on longitudinal tangle accumulation via tau phosphorylationSemantic proximity Read

Novel Plasma Proteins Associated With Alzheimer’s Disease Risk in APOE ε4 Carriers and Non-carriersSemantic proximity Read

APOE Genotype Modifies the Predictive Performance of Plasma Biomarkers for Amyloid Plaque Burden in Subjective Cognitive Decline.Semantic proximity Read

Predicting Preclinical Cognitive Decline Using Plasma P-tau217 and <i>APOE</i> Genotype in 8,582 Individuals From Different Ethnic GroupsSemantic proximity Read

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s diseaseSemantic proximity Read

APOEε4 potentiates amyloid β effects on longitudinal tau pathology.Semantic proximity Read

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.Semantic proximity Read

Genetic architecture of Alzheimer’s disease-related plasma biomarkersSemantic proximity Read

Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measuresSemantic proximity Read

Plasma p-tau217, p-tau181, and Aβ42 Predicts Amyloid PET Positivity in Cognitively Unimpaired AdultsSemantic proximity Read

Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohortSemantic proximity Read