Article

APOE <i>ε</i> 4-Associated Hippocampal Atrophy Trajectories Across the Alzheimer’s Disease Continuum: A Systematic Review, Meta-Analysis, and Longitudinal Validation

2025-12-11

Abstract excerpt

<h4>Background</h4> The role of APOE- ε 4 in hippocampal atrophy is contested. We aimed to determine whether it functions as a static risk factor or an amyloid- β (A β )-dependent modulator of neurodegeneration. <h4>Methods</h4> We integrated a systematic meta-analysis of 18 studies ( N = 3, 781) with longitudinal validation using linear mixed-effects models in the NACC and ADNI cohorts ( N > 5, 000), empl...

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Literature Corpus work: 54d636b1-eb84-5e8c-9eca-4e1471cfd163
DOI: 10.64898/2025.12.08.25341534

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