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<i>APOE</i> genotype and early β-amyloid accumulation in older adults without dementia

10 Aug 2017

Abstract excerpt

<h3>Objective:</h3> To clarify associations between <i>APOE</i> ε4 allele and age on longitudinal rates of β-amyloid (Aβ) accumulation within Aβ+ and Aβ− older individuals without dementia. <h3>Methods:</h3> We analyzed 595 older adults without dementia classified cross-sectionally as Aβ− (n = 325) and Aβ+ (n = 270) using longitudinal florbetapir PET. The influence of age and <i>APOE</i> genotype on longitudinal...

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PMID: 28794245
DOI: 10.1212/wnl.0000000000004336

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