Article

Escape of Kdm6a from X chromosome is detrimental to ischemic brains via IRF5 signaling

2024-09-27

Abstract excerpt

<title>Abstract</title> <p>The role of chromatin biology and epigenetics in disease progression is gaining increasing recognition. Genes that escape X chromosome inactivation (XCI) can impact neuroinflammation through epigenetic mechanisms. Our prior research has suggested that the X escapee genes <italic>Kdm6a</italic> and <italic>Kdm5c</italic> are involved in microglial activation after stroke in aged mice. Ho...

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Literature Corpus work: 4e5ea14d-e304-577e-9da2-d6ab9a27110f
DOI: 10.21203/rs.3.rs-4986866/v1

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