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Article

The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma

2024-06-06

Abstract excerpt

Whether an individual is a biological female or male affects cancer risk, but the responsible mechanisms and cell types remain obscure. Glioblastoma multiforme (GBM) is a male-biased cancer that is highly aggressive, and resistant to treatment, with poor patient survival. Dismal prognoses in GBM are due in part to the specialized immune system of the brain, consisting largely of microglia, which regulate GBM devel...

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Literature Corpus work
f38abd47-149f-5ab5-b665-359786efb738
DOI
10.1101/2024.06.06.597433
Open publication

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The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastomaDOI 10.1101/2024.06.06.597433
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