Article

Allele-specific epigenetic regulation of <i>FURIN</i> expression at a coronary artery disease susceptibility locus

2023-05-20

Abstract excerpt

<h4>Background</h4> Genome-wide association studies have revealed an association between the genetic variant rs17514846 on chromosome 15q26.1 and coronary artery disease susceptibility. Studies have shown that rs17514846 influences the expression of the FES Upstream Region ( FURIN ) gene located at this locus in monocytes. We investigated the mechanism through which rs17514846 modulates FURIN expression. <h4>M...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8d0a097-0121-57ea-a27d-b2039aea3a20
DOI: 10.1101/2023.05.19.541547

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Allele-specific epigenetic regulation of <i>FURIN</i> expression at a coronary artery disease susceptibility locusDOI 10.1101/2023.05.19.541547Read

Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus.Semantic proximity Read

Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior.Semantic proximity Read

FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration.Semantic proximity Read

Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via <i>PHACTR1</i> RegulationSemantic proximity Read

Causal SNP regulating <i>FAM13B</i> expression identified for the Chr. 5q31 atrial fibrillation susceptibility locusSemantic proximity Read

DNA Methylation Predicts Adverse Outcomes of Coronary Artery DiseaseSemantic proximity Read

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.Semantic proximity Read

CAD variants act through ox-LDL-induced enhancer remodelling to alter VSMC gene programmesSemantic proximity Read

Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries.Semantic proximity Read

Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease.Semantic proximity Read

Loss-of-function of <i>MFGE8</i> and protection against coronary atherosclerosisSemantic proximity Read

Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo.Semantic proximity Read