Article

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

2018-11-11

Abstract excerpt

<h4>SUMMARY</h4> Lysine 9 di-methylation and lysine 27 tri-methylation of histone H3 (H3K9me2 and H3K27me3) are generally linked to gene repression. However, the functions of repressive histone methylation dynamics during inflammatory responses remain enigmatic. We found that tumor necrosis factor (TNF)-α rapidly induces the co-occupancy of lysine demethylases 7A (KDM7A) and 6A (UTX) with nuclear factor kappa-B (...

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Literature Corpus work: 89ad8772-8016-5a47-884b-baca7ca12d4d
DOI: 10.1101/456491

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