Article

Chronic HDACi emends microglial differentiation and neurological disease in a mouse model of intellectual disability

2025-05-07

Abstract excerpt

Defect in lysine-specific methyltransferase 2D (KMT2D) underlies a rare intellectual disability disorder, Kabuki Syndrome (KS). We show that in addition to reduction in post-natal neurogenesis, KS mice present small, arrested hippocampal microglia which single cell RNA sequence analyses revealed as globally downregulated, occupying neither activated nor surveillance states. Weekly administration of a triple combin...

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Literature Corpus work: fcac2fe6-87a0-52c4-890d-17d50e91b3e3
DOI: 10.1101/2025.05.01.651719

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