Article
X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals.
Translational stroke research - 1 Oct 2023
Qi Shaohua, Ngwa Conelius, Al Mamun Abdullah, Romana Sharmeen, Wu Ting, Marrelli Sean P, Arnold Arthur P, McCullough Louise D, Liu Fudong
Abstract excerpt
Post-menopausal women become vulnerable to stroke and have poorer outcomes and higher mortality than age-matched men, and previous studies suggested that sex chromosomes play a vital role in mediating stroke sensitivity in the aged. It is unknown if this is due to effects of the X or Y chromosome. The present study used the XY* mouse model (with four genotypes: XX and XO gonadal females and XY and XXY gonadal...
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