Article

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs

2023-06-25

Abstract excerpt

Microglia are innate immune cells in the brain. Transcription factor IRF8 is highly expressed in microglia. However, its role in postnatal microglia development is unknown. We demonstrate that IRF8 binds stepwise to enhancer regions of postnatal microglia along with Sall1 and PU.1, reaching a maximum after day 14. IRF8 binding correlated with a stepwise increase in chromatin accessibility, which preceded the initi...

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Literature Corpus work: 825bd97d-38f9-502e-a1b1-3d394bf03b82
DOI: 10.1101/2023.06.25.546453

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