Article
Changes in microglia chromatin accessibility in aged female mice
2024-01-20
Abstract excerpt
Aged female microglia display a more inflammatory and disease-associated phenotype compared to age-matched males. Epigenetic mechanisms, such as chromatin accessibility, are key drivers of microglial plasticity and phenotypes necessary for development, priming, and immune activation. Therefore, alterations in chromatin accessibility patterns can potentially regulate the neuroimmune responses and phenotypes observe...
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Identifiers and source
- Literature Corpus work
- 18aaedaa-c3fd-5743-a75e-fa186a49ba5a
- DOI
- 10.1101/2024.01.18.575944