Article

Histone deacetylase 3 regulates microglial function through histone deacetylation

2022-09-10

Abstract excerpt

<h4>Background</h4> As the primary innate immune cells of the brain microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules. Histone acetylation is an activating transcriptional mark that regulates gene expression, which is altered in states of disease. Inhibition of histone deacetylase 3 (Hdac3) has been utilized in pre-clinical models of disease to d...

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Literature Corpus work: e11b2df0-cc62-505e-8585-d223835ec426
DOI: 10.1101/2022.09.08.507183

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