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Article

X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals.

Journal of neuroinflammation - 12 Mar 2021

Qi Shaohua, Al Mamun Abdullah, Ngwa Conelius, Romana Sharmeen, Ritzel Rodney, Arnold Arthur P, McCullough Louise D, Liu Fudong

Abstract excerpt

BACKGROUND: Stroke is a sexually dimorphic disease. Previous studies have found that young females are protected against ischemia compared to males, partially due to the protective effect of ovarian hormones, particularly estrogen (E2). However, there are also genetic and epigenetic effects of X chromosome dosage that contribute to stroke sensitivity and neuroinflammation after injury, especially in the aged....

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Share to Chromatin Immunoprecipitation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33712031
DOI: 10.1186/s12974-021-02120-3
PMCID: PMC7953638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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