Article

YAP levels regulate anteroposterior elongation of hESC-derived gastruloids

2025-12-02

Abstract excerpt

<h4>SUMMARY</h4> Human embryonic stem cells (hESCs) can self-organize into anteroposterior patterned three-dimensional structures, characterized by polarized expression of CDX2 and GATA6, known as human 3D gastruloids (h3D-gastruloids) . This patterning emerges through hESC-intrinsic mechanisms that remain poorly understood. Here, we demonstrate that the formation and elongation of h3D -gastruloids is modulated...

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Literature Corpus work: 4e035940-5219-52ab-b472-30659905e577
DOI: 10.64898/2025.12.01.691265

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