Article

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Human gastruloids are a powerful class of stem cell-derived models that recapitulate key features of early embryonic development, including symmetry breaking and the emergence of three germ layers 1–3 . However, they lack anterior embryonic structures and coordinated axial organization 4–6 . To address this limitation, we pre-patterned human pluripotent stem cells (hPSCs) by exposing them to e...

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Literature Corpus work: de87f489-18de-5094-90e7-c733fe2ee1ae
DOI: 10.1101/2025.09.25.678678

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