Article

YAP1 Regulates the Self-organized Fate Patterning of hESCs-Derived Gastruloids

2021-03-12

Abstract excerpt

<h4>ABSTRACT</h4> During gastrulation, the coordinated activity of BMP, WNT and NODAL signaling pathways guide the differentiation of the pluripotent epiblast into the three germinal layers. Recent studies underline the role of the Hippo-effector YAP1 regulating WNT and NODAL signaling pathways and repressing mesoendodermal differentiation in human embryonic stem cells (hESCs). However, the contribution of YAP1 t...

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Literature Corpus work: dd145b3a-4747-589e-9344-b0569ad4f646
DOI: 10.1101/2021.03.12.434631

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