Article

Coupled organoids reveal that signaling gradients drive traveling segmentation clock waves during human axial morphogenesis

2022-05-11

Abstract excerpt

<h4>Summary</h4> Axial development of mammals is a dynamic process involving several coordinated morphogenetic events including axial elongation, somitogenesis, and neural tube formation. How different signals control the dynamics of human axial morphogenesis remains largely unknown. By inducing anteroposterior symmetry breaking of spatially coupled epithelial cysts derived from human pluripotent stem cells, we w...

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Literature Corpus work: f2ff3f46-9884-540a-bae3-85eef22e52de
DOI: 10.1101/2022.05.10.491359

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