Article

High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human embryonic stem cell gastruloid cultures

2020-01-23

Abstract excerpt

<h4>Summary</h4> During mammalian gastrulation, germ layers arise and are shaped into the body plan while extraembryonic layers sustain the embryo. Human embryonic stem cells, cultured with BMP4 on extracellular matrix micro-discs, reproducibly differentiate into gastruloids, expressing markers of germ layers and extraembryonic cells with radial organization. Single-cell RNA sequencing and cross-species compariso...

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Literature Corpus work: 682c1972-679f-57a0-8fd2-eae0e3cb41e0
DOI: 10.1101/2020.01.22.915777

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