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Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids

22 Apr 2021

Abstract excerpt

Human embryonic stem cells cultured in 2D micropatterns with BMP4 differentiate into a radial arrangement of germ layers and extraembryonic cells. Single-cell transcriptomes demonstrate generation of cell types transcriptionally similar to their in vivo counterparts in Carnegie stage 7 human gastrula. Time-course analyses indicate sequential differentiation, where the epiblast arises by 12 h between the...

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PMID: 33891870
DOI: 10.1016/j.stemcr.2021.03.031

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