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3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation

22 Jul 2021

Abstract excerpt

3D gastruloids, aggregates of embryonic stem cells that recapitulate key aspects of gastrula-stage embryos, have emerged as a powerful tool to study the early stages of mammalian post-implantation development in vitro. Owing to their tractable nature and the relative ease by which they can be generated in large numbers, 3D gastruloids provide an unparalleled opportunity to study normal and pathological...

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PMID: 34304959
DOI: 10.1016/j.tcb.2021.06.007

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