Article

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast

2025-06-17

Abstract excerpt

<h4>ABSTRACT</h4> YAP1 signaling is essential for development but its specific roles in early embryogenesis remain poorly understood. To shed light on this, we analyzed YAP1’s role in regulating the pluripotency of the mammalian epiblast, using scRNAseq approaches. Conditional deletion of Yap1 in the mouse epiblast ( Sox2 -Cre) altered the expression of signaling genes, including Nodal , Wnt3 , and Fgf8 . Ac...

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Literature Corpus work: 8b6a20b9-b72e-5647-a3bb-d997dd977d52
DOI: 10.1101/2025.06.16.659935

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