Article

Induction and <i>in silico</i> staging of human gastruloids with neural tube, segmented somites & advanced cell types

2024-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Embryonic organoids are emerging as powerful models for studying early mammalian development. For example, stem cell-derived ‘gastruloids’ form elongating structures containing all three germ layers 1–4 . However, although elongated, human gastruloids do not morphologically resemble post-implantation embryos. Here we show that a specific, discontinuous regimen of retinoic acid (RA) robustly ind...

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Literature Corpus work: 4dd44600-db7b-52d5-b402-0d745e16b1cd
DOI: 10.1101/2024.02.10.579769

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