Article

Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem Cells

2024-03-29

Abstract excerpt

<h4>ABSTRACT</h4> The spinal cord, nerves, and skeletal muscles arise from neuromesodermal progenitors (NMPs). We have developed a growth-factor screening strategy, utilizing ES and iPS cells, facilitating the indefinite self-renewal of two types of human axial stem cells (AxSCs), closely resembling mouse NMPs (NM-AxSCs) and posterior neural tube progenitors (N-AxSCs). Under specific regimens— Wnt/CHIR99021, FGF2...

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Literature Corpus work: 4d51b557-1db9-5266-8ad4-3a100972ca7f
DOI: 10.1101/2024.03.26.586760

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