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Modular Derivation and Unbiased Single-cell Analysis of Regional Human Hindbrain And Spinal Neurons Enables Discovery of Nuanced Transcriptomic Patterns along Developmental Axes

2021-10-15

Abstract excerpt

<h4>Summary</h4> Our inability to derive the vast neuronal diversity of the posterior central nervous system (pCNS) using human pluripotent stem cells (hPSCs) poses a major impediment to understanding human neurodevelopment and disease in the hindbrain and spinal cord. Here we establish a modular differentiation paradigm that recapitulates patterning along both the rostrocaudal (R/C) and dorsoventral (D/V) axes o...

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Literature Corpus work: 84caa1e1-aadc-51c4-813e-d0d5c7ac59db
DOI: 10.1101/2021.10.14.464440

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