Article

Capturing self-renewing multipotent neural crest stem cells from human pluripotent stem cells

2026-01-20

Abstract excerpt

During embryonic development, neural crest cells (NCCs) represent a multipotent population characterized by an inherently transient nature, rapidly differentiating into various lineages. This instability has presented a fundamental challenge, as it is exceedingly difficult to maintain these cells in a stable, multipotent state in vitro. In this study, we report a robust culture system dependent on Wnt and FGF sign...

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Literature Corpus work: d1bd95af-b6c4-51c7-b2bf-7d5511ed4e8d
DOI: 10.64898/2026.01.18.700209

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