Article

Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro

2020-06-16

Abstract excerpt

<h4>ABSTRACT</h4> The spinal cord emerges from a niche of neuromesodermal progenitors (NMPs) formed and maintained by Wnt/FGF signals at the posterior end of the embryo. NMPs can be generated from human pluripotent stem cells and hold promise for spinal cord replacement therapies. However, NMPs are transient, which complicates the full range production of rostrocaudal spinal cord identities in vitro . Here we re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc2d07fb-452e-5cb7-b933-6f821846dbf9
DOI: 10.1101/2020.06.16.155564

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitroDOI 10.1101/2020.06.16.155564Read

Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem CellsSemantic proximity Read

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivativesSemantic proximity Read

Capturing self-renewing multipotent neural crest stem cells from human pluripotent stem cellsSemantic proximity Read

Human neural crest cells display molecular and phenotypic hallmarks of stem cells.Semantic proximity Read

A Mesenchymal-Like ZEB1+ Niche Harbors Dorsal Radial Glial Fibrillary Acidic Protein-Positive Stem Cells in the Spinal CordSemantic proximity Read

Human-specific progenitor sub-domain contributes to extended neurogenesis and increased motor neuron productionSemantic proximity Read

Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitroSemantic proximity Read

Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identitySemantic proximity Read

Posterior specification of multi-lineage axial assembloids from human pluripotent stem cellsSemantic proximity Read

Global Transcriptional Analyses of the Wnt-Induced Development of Neural Stem Cells from Human Pluripotent Stem CellsSemantic proximity Read

Species-specific progenitor sub-domain extends neurogenesis and increases human motor neuron productionSemantic proximity Read

Neural crest-like stem cells for tissue regenerationSemantic proximity Read