Article

Axial Elongation of Caudalized Human Organoids Mimics Neural Tube Development

2020-03-06

Abstract excerpt

Axial elongation of the neural tube is critical during mammalian embryogenesis to establish the anterior-posterior body axis 1 , but this process is difficult to interrogate directly because it occurs post-implantation 2,3 . Here we report an organoid model of neural tube extension by caudalized human pluripotent stem cell (hPSC) aggregates that recapitulates the morphologic and temporal gene expression patterns...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 17022ef7-308e-5c8b-876e-3295ac6601b3
DOI: 10.1101/2020.03.05.979732

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Axial Elongation of Caudalized Human Organoids Mimics Neural Tube DevelopmentDOI 10.1101/2020.03.05.979732Read

Posterior specification of multi-lineage axial assembloids from human pluripotent stem cellsSemantic proximity Read

Comparative human embryo-mapping reveals neural bias of neuromesodermal progenitors in stem cell axial elongation modelsSemantic proximity Read

Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem CellsSemantic proximity Read

Coupled organoids reveal that signaling gradients drive traveling segmentation clock waves during human axial morphogenesisSemantic proximity Read

Machine learning directed organoid morphogenesis uncovers an excitable system driving human axial elongationSemantic proximity Read

Reconstituting human somitogenesis in vitro.Semantic proximity Read

Human trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and diseaseSemantic proximity Read

Dynamic modelling of human neural crest development using a bioengineered stem cell organoid systemSemantic proximity Read

Reconstituting human somitogenesis <i>in vitro</i>Semantic proximity Read

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterningSemantic proximity Read

Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identitySemantic proximity Read

In vitro spatiotemporal reconstruction of human skeletal muscle organogenesisSemantic proximity Read