Article

Epigenomic manipulation reveals the relationship between locus specific chromatin dynamics and gene expression

2024-07-19

Abstract excerpt

<h4>Summary</h4> Dysregulation of epigenetic processes leads to a plethora of abnormalities including disease states such as cancer. Therapies focused on epigenetic modulation alter gene expression to correct dysfunction, though the mechanisms and perpetuation of these states is unknown. Here, we use integrated epigenomics and three-dimensional chromatin structure-function analyses after acute histone deacetylase...

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Literature Corpus work: 4d2809a7-7765-512b-9042-c03c896aa783
DOI: 10.1101/2024.07.17.603961

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