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Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeutics

1 Mar 2009

Abstract excerpt

The eukaryotic genome is a highly dynamic nucleoprotein complex that is comprised of DNA, histones, nonhistone proteins and RNA, and is termed as chromatin. The dynamic of the chromatin is responsible for the regulation of all the DNA-templated phenomena in the cell. Several factors, including the nonhistone chromatin components, ATP-dependent remodeling factors and the chromatin-modifying enzymes, mediate the...

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PMID: 19296442
DOI: 10.1002/biot.200900032

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