Article
Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci.
Nature genetics - 1 May 2021
Sungalee Stephanie, Liu Yuanlong, Lambuta Ruxandra A, Katanayeva Natalya, Donaldson Collier Maria, Tavernari Daniele, Roulland Sandrine, Ciriello Giovanni, Oricchio Elisa
Abstract excerpt
In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is affected by these events is unclear. In the present study, by comparing chromatin structure and H3K27ac levels in normal and lymphoma B cells, we show that...
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