Article

Breast cancer identity is defined by specialized enhancer sets via lysine deacetylation

2025-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer subtypes are defined by distinct transcriptional programs, yet the epigenetic mechanisms underlying subtype-specific gene regulation remain unclear. Enhancers, key regulators of gene expression and cell identity, are well positioned to define breast cancer subtypes. Here, we identify a previously unrecognized class of enhancers, termed hypoacetylation-defined (HD) enhancers, that r...

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Literature Corpus work: bdda7adc-a89a-5a29-b226-f6a3a63ce59b
DOI: 10.1101/2025.07.31.668008

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