Article
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
Molecular cell - 2 Jun 2016
Soshnev Alexey A, Josefowicz Steven Z, Allis C David
Abstract excerpt
Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes. Advances in genome editing, visualization technology, and genome-wide analyses have revealed unprecedented complexity of chromatin pathways,...
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