Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.

doi:10.1016/j.molcel.2016.05.004

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Article

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.

Molecular cell - 2 Jun 2016

Soshnev Alexey A, Josefowicz Steven Z, Allis C David

Abstract excerpt

Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes. Advances in genome editing, visualization technology, and genome-wide analyses have revealed unprecedented complexity of chromatin pathways,...

Topics

Animals
Cell Transformation, Neoplastic
Chromatin Assembly and Disassembly
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Histones
Humans
Methylation
Models, Molecular
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms

Nucleic Acid Conformation

Oncogenes

Phosphorylation

Protein Binding

Protein Conformation

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 27259201
DOI: 10.1016/j.molcel.2016.05.004
PMCID: PMC4898265

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