Article

Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress

2024-12-16

Abstract excerpt

RNase H2 is a heterotrimeric endoribonuclease that resolves RNA:DNA hybrids and genome-embedded ribonucleotides, which are implicated in DNA replication stress and cancer development. Protein and/or mRNA levels of individual RNase H2 subunits are elevated in some cancers, but little is known about the mechanisms or consequences of RNase H2 upregulation. We report that RNase H2 subunits are upregulated at the prote...

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Literature Corpus work: 4ce63fd4-1f74-557a-a80b-a912b7a9bd32
DOI: 10.1101/2024.12.16.628316

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