Article

RNase H1 levels dramatically affect mitochondrial genome maintenance with little impact on nuclear R-loops in murine B cells

2025-04-30

Abstract excerpt

<h4>ABSTRACT</h4> Overexpression of RNase H1, a ribonuclease that degrades RNA:DNA hybrids and R-loops, can suppress genome instability phenotypes in a range of maladaptive conditions. This has been interpreted to suggest that genotoxic co-transcriptional R-loops arise under these conditions and are resolved by RNase H1. Here, we manipulated RNase H1 levels using conditional knockout and overexpression models in...

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Literature Corpus work: 87363ed0-95e3-57d2-81e3-17acebff5c6a
DOI: 10.1101/2025.04.30.651504

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