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Article

Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork.

The Journal of biological chemistry - 15 Sept 2017

Parajuli Shankar, Teasley Daniel C, Murali Bhavna, Jackson Jessica, Vindigni Alessandro, Stewart Sheila A

Abstract excerpt

Faithful DNA replication is essential for genome stability. To ensure accurate replication, numerous complex and redundant replication and repair mechanisms function in tandem with the core replication proteins to ensure DNA replication continues even when replication challenges are present that could impede progression of the replication fork. A unique topological challenge to the replication machinery is posed...

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Share to DNA Replication
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Nucleic Acid Conformation

Share to Nucleic Acid Hybridization

Share to Replication Origin

Share to Ribonuclease H

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Source

Open in PubMed Open full text

Identifiers

PMID: 28717002
DOI: 10.1074/jbc.M117.787473
PMCID: PMC5602383

Genes

RNH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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