Article

HSATII RNA is induced <i>via</i> a non-canonical ATM-regulated DNA-damage response pathway and facilitates tumor cell proliferation and movement

2020-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Pericentromeric human satellite II (HSATII) repeats are normally silent, but can be actively transcribed in tumor cells, where increased HSATII copy number is associated with a poor prognosis in colon cancer, and in human cytomegalovirus (HCMV)-infected cells, where the RNA facilitates viral replication. Here, we report that HCMV infection or treatment of ARPE-19 diploid epithelial cells with th...

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Literature Corpus work: d7f86e86-3c78-5361-8ba0-a56d72c351b6
DOI: 10.1101/2020.05.25.115238

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