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Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

17 Apr 2017

Abstract excerpt

Replication stress is a characteristic feature of cancer cells, which is resulted from sustained proliferative signaling induced by activation of oncogenes or loss of tumor suppressors. In cancer cells, oncogene-induced replication stress manifests as replication-associated lesions, predominantly double-strand DNA breaks (DSBs). An essential mechanism utilized by cells to repair replication-associated DSBs is...

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PMID: 28414320
DOI: 10.1038/oncsis.2017.15

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