Article

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

2017-02-09

Abstract excerpt

Replication stress is a characteristic feature of cancer cells, which is resulted from sustained proliferative signaling induced by activation of oncogenes or loss of tumor suppressors. In cancer cells, oncogene-induced replication stress manifests as replication-associated lesions, predominantly double-strand DNA breaks (DSBs). An essential mechanism utilized by cells to repair replication-associated DSBs is homo...

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Literature Corpus work: aa223a99-2c31-5408-aa15-03177a11c9da
DOI: 10.1101/107383

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